F35- based vaccines targeting GUCY2C, or other tumor or pathogen antigens, may produce clinically relevant immune responses in more … We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment … Immunization with GUCY2C-based vaccines produces memory CD8+ T-cell responses that provide durable protection against metastases in mice, modeling vaccination in CRC patients …. Patient blood samples were collected before (day 0) and 30, 90 and 180 days after Ad5-GUCY2C-PADRE immunization. Endogenous GUCY2C-activating ligands disappear early in … For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. … Immunization with GUCY2C-based vaccines produces memory CD8+ T-cell responses that provide durable protection against metastases in mice, modeling vaccination in CRC patients … Cancer is one of the major global health burdens, and more effective treatments are needed. F35 + Lm vaccination regimens and demonstrate that optimal GUCY2C-specific immunity (T-cell quantity, avidity, and … Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C-specific CD8 + T-cell responses towards the dominant H-2K d -restricted epitope, GUCY2C 254-262. The progress in the development of … Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). Collectively, these data support Ad5-GUCY2C-PADRE as a safe and effective vaccination strategy in preclinical models and position Ad5-GUCY2C-PADRE for Phase I … Here, we combined an adenoviral-based vaccine against the colorectal cancer antigen guanylyl cyclase C (GUCY2C) with different schedules of tumor-directed RT to augment local and … Immune responses were assessed by ELISpot and clinical responses were assessed by tumor size and incidence. Results: The specific sequence of tumor-directed RT … Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor … More specifically, Lm-GUCY2C may be utilized to amplify GUCY2C-specific immunity in patients receiving adenovirus-based GUCY2C vaccines currently in clinical trials … This study characterized the biodistribution, immunogenicity, and safety of a vector expressing GUCY2C fused with the human CD4+ T helper cell epitope PADRE (Ad5-GUCY 2C-PADRE) … After vaccination with GUCY2C-expressing adenovirus (Ad5-GUCY2C), colitis was induced with dextran sodium sulfate (DSS), to investigate if intestinal dysfunction due to inflammatory bowel … Subsequent studies of GUCY2C tolerance uncovered a previously unknown mechanism of self-tolerance mediated by selective CD4 + T-cell tolerance with preservation of … Here, we examined the immunogenicity of an Lm-based vaccine expressing the colorectal cancer antigen guanylyl cyclase C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C … Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C failed to prime … Phase 2A trial of Ad5. To date, over 30 clinical trials have been initiated testing Lm … A modified adenovirus AD5. Ten percent of patients … Supporting: 1, Mentioning: 56 - Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8 + , but not CD4 + , T-cell responses that … To overcome this challenge, we generated a GUCY2C vaccine employing a chimeric viral vector composed of the Ad5 capsid and Ad35 fiber protein (Ad5. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a | T Lymphocytes, Colon Cancer and Colorectal Cancer | ResearchGate, the professional network for scientists. induce antigen-specific CD8+ T-cell and antibody re- Ad5 vectors have … More specifically, Lm-GUCY2C may be utilized to amplify GUCY2C-specific immunity in patients receiving adenovirus-based GUCY2C vaccines currently in clinical trials to prevent or treat … Minimal residual disease by circulating tumor DNA as a biomarker of recurrence free survival in resected high-risk melanoma patients treated with mRNA-4157/V940, a personalized cancer … Background Ad5-GUCY2C-PADRE is a replication-deficient human type 5 recombinant adenovirus (Ad5) vaccine encoding guanylyl cyclase C (GUCY2C) fused to the … Forty percent of patients demonstrated GUCY2C-specific T-cell responses, all of which were CD8-positive T cells. GUCY2C-specific T cell … To overcome this challenge, we generated a GUCY2C vaccine employing a chimeric viral vector composed of the Ad5 capsid and Ad35 fiber protein (Ad5. Compositions comprising a … Three Primary Modalities for GUCY2C-directed Cancer Immunotherapy. … In the study, immunization with GUCY2C-based vaccines generated memory CD8 + T-cell responses that provided durable … Conversely, mice bearing GUCY2C-deficient (CT26-WT) or GUCY2C-expressing (CT26-GUCY2C) tumors received 8 Gy radiation to the tumor … Here, we examined the immunogenicity of an Lm-based vaccine expressing the colorectal cancer antigen guanylyl cyclase C (Lm-GUCY2C).

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Gucy2c vaccine.